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OxyContin 40mg Tablets
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Patient Information Leaflet
Your medicine is called OxyContin 20mg Tablets but will be referred to as
OxyContin tablets throughout the leaflet.
Read all of this leaflet carefully before you start taking this medicine
because it contains important information for you.
Keep this leaflet. You may need to read it again.
If you have any further questions, ask your doctor or pharmacist.
* This medicine has been prescribed for you only. Do not pass it on to
others. It may harm them, even if their signs of illness are the same as
* If you get any side effects, talk to your doctor or pharmacist. This includes
any possible side effects not listed in this leaflet. See section 4.
What is in this leaflet
What OxyContin tablets are and what they are used for
What you need to know before you take OxyContin tablets
How to take OxyContin tablets
Possible side effects
How to store OxyContin tablets
Contents of the pack and other information
What OxyContin tablets are and what they are used
These tablets have been prescribed for you by your doctor to relieve
moderate to severe pain over a period of 12 hours. They contain the active
ingredient oxycodone which belongs to a group of medicines called strong
analgesics or ‘painkillers’.
What you need to know before you take OxyContin
Do not take OxyContin tablets if you:
are allergic (hypersensitive) to oxycodone, or any of the other ingredients
of the tablets (listed in section 6’);
have breathing problems, such as severe chronic obstructive lung disease,
severe bronchial asthma or severe respiratory depression. Your doctor will
have told you if you have any of these conditions. Symptoms may include
breathlessness, coughing or breathing more slowly or weakly than
* have a condition where the small bowel does not work properly (paralytic
ileus), your stomach empties more slowly than it should (delayed gastric
emptying) or you have severe pain in your abdomen.
* have a heart problem after long-term lung disease (cor pulmonale);
* have moderate to severe liver problems. If you have other long-term liver
problems you should only take these tablets if recommended by your
* have ongoing problems with constipation;
* are under 18 years of age.
Warnings and precautions
Talk to your doctor or pharmacist before taking these tablets if you:
* are elderly or weakened;
* have an under-active thyroid gland (hypothyroidism), as you may need a
* have myxoedema (a thyroid disorder with dryness, coldness and swelling
(‘puffiness’) of the skin, affecting the face and limbs;
* have a head injury, severe headache or feel sick as this may indicate that
the pressure in your skull is increased
* have low blood pressure (hypotension)
* have low blood volume (hypovolaemia); this can happen with severe
external or internal bleeding, severe burns, excessive sweating, severe
diarrhoea or vomiting;
* have a mental disorder as a result of an infection (toxic psychosis);
* have inflammation of the pancreas (which causes severe pain in the
abdomen and back)
* have problems with your gall bladder or bile duct;
* have inflammatory bowel disease;
* have an enlarged prostate gland, which causes difficulty in passing urine
*have poor adrenal gland function (your adrenal gland is not working
properly which may cause symptoms including weakness, weight loss,
dizziness, feeling or being sick), e.g. Addison’s disease;
* have breathing problems such as severe pulmonary disease. Your doctor
will have told you if you have this condition. Symptoms may include
breathlessness and coughing;
* have kidney or liver problems;
* have previously suffered from withdrawal symptoms such as agitation,
anxiety, shaking or sweating, upon stopping taking alcohol or drugs;
* are or have ever been addicted to alcohol or drugs or have a known
have an increased sensitivity to pain;
* need to take increasingly higher doses of OxyContin to gain the same
level of pain relief (tolerance).
If you are going to have an operation, please tell the doctor at the hospital
that you are taking these tablets.
Other medicines and OxyContin
Please tell your doctor or pharmacist if you are taking, have recently taken
or might take any other medicines, including medicines obtained without a
prescription. If you take these tablets with some other medicines, the effect
of these tablets or the other medicine may be changed.
Tell your doctor or pharmacist if you are taking:
* a type of medicine known as a monoamine oxidase inhibitor or you have
taken this type of medicine in the last two weeks;
* medicines to help you sleep or stay calm (for example tranquillisers,
hypnotics or sedatives);
* medicines to treat depression (such as paroxetine);
* medicines to treat psychiatric or mental disorders (such as phenothiazines
or neuroleptic drugs);
* other strong analgesics (‘painkillers’);
* muscle relaxants;
* medicines to treat high blood pressure;
* quinidine (a medicine to treat a fast heart beat);
* cimetidine (a medicine for stomach ulcers, indigestion or heartburn);
* antifungal medicines (such as ketoconazole, voriconazole, itraconazole
antibiotics (such as clarithromycin, erythromycin or telithromycin);
medicines known as ‘protease inhibitors’ to treat HIV (e.g. boceprevir,
ritonavir, indinavir, nelfinavir or saquinavir);
rifampicin (to treat tuberculosis);
carbamazepine (a medicine to treat seizures, fits or convulsions and
certain pain conditions)
phenytoin (a medicine to treat seizures, fits or convulsions);
a herbal remedy called St. John’s Wort (also known as Hypericum
medicines to treat Parkinson’s disease.
Also tell your doctor if you have recently been given an anaesthetic.
Taking OxyContin tablets with food, drink and alcohol
Drinking alcohol whilst taking OxyContin tablets may make you feel more
sleepy or increase the risk of serious side effects such as shallow breathing
with a risk of stopping breathing, and loss of consciousness. It is
recommended not to drink alcohol while you’re taking OxyContin tablets.
You should avoid drinking grapefruit juice during your treatment with this
Pregnancy and breastfeeding
Do not take these tablets if you are pregnant or breastfeeding.
Ask your doctor or pharmacist for advice before taking any medicine.
Driving and using machines
These tablets may cause a number of side effects such as drowsiness which
could affect your ability to drive or use machinery (see section 4 for a full list
of side effects). These are usually most noticeable when you first start taking
the tablets, or when changing to a higher dose. If you are affected you
should not drive or use machinery.
This medicine can affect your ability to drive as it may make you sleepy or
Do not drive while taking this medicine until you know how it affects you.
It is an offence to drive while you have this medicine in your body over a
specified limit unless you have a defence (called the ‘statutory defence’).
This defence applies when:
The medicine has been prescribed to treat a medical or dental
You have taken it according to the instructions given by the prescriber
and in the information provided with the medicine.
Please note that it is still an offence to drive if you are unfit because of the
medicine (i.e. your ability to drive is being affected).
Details regarding a new driving offence concerning driving after drugs have
been taken in the UK may be found here:
Talk to your doctor or pharmacist if you are not sure whether it is safe for
you to drive while taking this medicine.
OxyContin tablets contain lactose
These tablets contain lactose which is a form of sugar. If you have been told
by your doctor that you have an intolerance to some sugars, contact your
doctor before taking these tablets.
How to take OxyContin tablets
Always take these tablets exactly as your doctor has told you. The label on
your medicine will tell you how many tablets to take and how often.
Adults (over 18 years of age)
The usual starting dose is one 10 mg tablet every 12 hours. However, your
doctor will prescribe the dose required to treat your pain. If you find that you
are still in pain whilst taking these tablets discuss this with your doctor.
Do not exceed the dose recommended by your doctor. You should check
with your doctor or pharmacist if you are not sure.
Swallow your tablets whole with water.
Do not crush, dissolve or chew them.
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